Blood Pyruvic Acid in Thalidomide Neuropathy

Pathological Variations in Blood and Spinal Fluid Pyruvic Acid.

Pyruvic acid is a normal intermediary of carbohydrate metabolism (1, 2). It has been previously demonstrated that thiamin, or more particularly thiamin pyrophosphate (cocarboxylase), is concerned in the normal catabolism of pyruvic acid (1). In Oriental beri-beri (3) and peripheral neuropathy in the alcohol addict (4)-both diseases associated with a deficiency of thiaminhyperpyruvemia does occu...

Pyruvic Acid I. Collection of Blood for the Determination of Pyruvic and Lactic Acids*

The accurate determination of pyruvic and lactic acids is a matter of considerable theoretical and practical importance. These acids play a role in the metabolism of carbohydrates, and they are found in increased concentration in the blood in conditions of thiamine deficiency. Recently we suggested (1) the determination of the ratio of lactic to pyruvic acid in the blood as a measure of oxidati...

The Determination of Pyruvic Acid in Blood in the Presence of Acetoacetic Acid

Photochemistry of aqueous pyruvic acid.

The study of organic chemistry in atmospheric aerosols and cloud formation is of interest in predictions of air quality and climate change. It is now known that aqueous phase chemistry is important in the formation of secondary organic aerosols. Here, the photoreactivity of pyruvic acid (PA; CH3COCOOH) is investigated in aqueous environments characteristic of atmospheric aerosols. PA is current...

The blood pyruvic acid level in renal diseases and in uraemic coma.

In the course of investigating the blood pyruvic acid levels we examined, amongst others, comatose patients with renal failure due to chronic nephritis and found the level to be normal. This finding was in contrast with that of high blood pyruvic acid levels in patients in coma due to other causes, e.g., hepatic (Snell and Butt, 1941 ; Amatuzio and Nesbitt, 1950; Carfagno, De Horatius, and Schw...